Glossary · The science

What is an entourage effect?

Entourage Effect

The hypothesis that cannabinoids, terpenes, and other plant compounds work synergistically to produce greater therapeutic effects than any single compound alone. This underpins the preference for full-spectrum over isolated CBD products in clinical prescribing.

Related terms

  • CBD (Cannabidiol)

    The second most studied cannabinoid. Non-intoxicating. Has anti-inflammatory, anxiolytic, anticonvulsant, and analgesic properties. Used in Epidyolex (licensed for epilepsy) and as a component in many unlicensed CBPMs.

  • Allodynia

    Pain caused by a stimulus that does not normally provoke pain, such as light touch or clothing against the skin. Common in neuropathic pain conditions.

  • Antiemetic

    A drug that prevents or treats nausea and vomiting. Cannabinoids, particularly THC and nabilone, have antiemetic properties used in chemotherapy-induced nausea.

  • Anxiolytic

    A medication or substance that reduces anxiety. CBD has well-documented anxiolytic properties.

  • CB1 Receptor (Cannabinoid Receptor Type 1)

    A receptor found primarily in the central nervous system and brain. THC binds to CB1 receptors, producing its psychoactive and analgesic effects.

This is a plain-language definition for general understanding, not medical or legal advice.

All 101 terms